Improving Bioavailability of Cefpodoxime Proxetil by Increasing Retention Time in Stomach with the Help of Natural Polymer: Formulation and Evaluation
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چکیده
منابع مشابه
Cefpodoxime Proxetil Floating Microspheres: Formulation and In Vitro Evaluation
The objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper GIT, which may result in enhanced absorption and thereby improved bioavailability. The microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (HPMC K 15 M), ethyl cellulo...
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abstract while task-based instruction is considered as the most effective way to learn a language in the related literature, it is oversimplified on various grounds. different variables may affect how students are engaged with not only the language but also with the task itself. the present study was conducted to investigate language and task related engagement on the basis of the task typolog...
15 صفحه اولFormulation and in vitro characterization of cefpodoxime proxetil gastroretentive microballoons
BACKGROUND AND THE PURPOSE OF THE STUDY The objective of the present work was to improve bioavailability of cepodoxime proxetil through gastroretentive microballoon formulation. METHODS Microballoons of cefpodoxime proxetil were formulated by solvent evaporation and diffusion method employing hydroxypropylmethyl cellulose (HPMC) and ethyl cellulose (EC) polymers and characterized for particle...
متن کاملGastro-retentive dosage form for improving bioavailability of Cefpodoxime proxetil in rats.
Cefpodoxime proxetil (CP) is a prodrug with poor oral bioavailability because of its metabolism to Cefpodoxime acid (CA) in luminal contents and intestinal epithelial cells. In the present investigation, regional variability in different segments of the gastrointestinal tract vis-à-vis solubility and metabolism were investigated, and the results indicated potential for a gastro retentive (GR) d...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutical Investigation
سال: 2020
ISSN: 2230-973X,2230-9713
DOI: 10.5530/ijpi.2020.3.65